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Eden Fragrance study

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Eden Fragrance study

The project, supported by the Research Institute for Fragrance Materials and coordinated by Centro Studi GISED in the framework of an European collaboration, was aimed to assess the prevalence of fragrance contact allergy.

A representative sample of 12,377 subjects (53.9% females, median age 43 years) of the adult population in several European countries (Italy, The Netherlands, Germany, Sweden, Portugal) was interviewed. Among these, a random sample of 3,119 subjects also performed patch testing for perfume allergy.


Results of the study were published by several scientific journals:

Bruze M, Engfeldt M, Elsner P, et al. Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II: The EDEN Fragrance Study. J Eur Acad Dermatol Venereol. 2021 Apr 29.

Bruze M, Mowitz M, Ofenloch et al. The significance of batch and patch test method in the establishing of contact allergy to fragrance mix I. EDEN fragrance study group. Contact Dermatitis. 2019 Feb 27.

Ofenloch RF, Schuttelaar ML, Svensson Å, et al. Socioeconomic Status and the Prevalence of Skin and Atopic Diseases in Five European Countries. Acta Derm Venereol. 2019;99:309-314.

Svensson A, Ofenloch RF, Bruze M, et al. Prevalence of skin disease in a population-based sample of adults from five European countries. Br J Dermatol. 2018;178:1111-1118.

Schuttelaar MLA, Ofenloch RF, Bruze M, et al. Prevalence of contact allergy to metals in the European general population with a focus on nickel and piercings: The EDEN Fragrance Study. Contact Dermatitis. 2018;79:1-9.

Diepgen TL, Ofenloch RF, Bruze M, et al. Colophony as marker for fragrance allergy in the general European population. Br J Dermatol. 2016;174:695-6

Diepgen TL, Naldi L, Bruze M, et al. Prevalence of contact allergy to p-phenylenediamine (PPD) in the European general population. J Invest Dermatol. 2016;136:409-15.

Diepgen TL, Ofenloch RF, Bruze M, et al. Prevalence of contact allergy in the general population in different European regions. Br J Dermatol. 2016;174:319-29.

Diepgen TL, Ofenloch RF, Bruze M, et al. Prevalence of fragrance contact allergy in the general population of five European countries – a cross-sectional study. Br J Dermatol 2015;173:1411-9.

Vogel TA, Coenraads PJ, Bijkersma LM, et al. p-Phenylenediamine exposure in real life?-?a case-control study on sensitization rate, mode and elicitation reactions in the northern Netherlands. Contact Dermatitis. 2015;72:355-61.

Naldi L, Cazzaniga S, Gonçalo M, et al. EDEN Fragrance Study Group. Prevalence of self-reported skin complaints and avoidance of common daily life consumer products in selected European Regions. JAMA Dermatol. 2014;150:154-63.

Rossi M, Coenraads PJ, Diepgen T, et al. Design and feasibility of an international study assessing the prevalence of contact allergy to fragrances in the general population: the European Dermato-Epidemiology Network Fragrance Study. Dermatology. 2010;221:267-75.

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